Over the past few years in Australia, peptides like TB-500 have gained more popularity globally due to their effective applications in the treatment of some health conditions.
Most peptides are usually associated with bodybuilding, but Thymosin Beta-500 is capable of doing much more than just this.
TB-500 is effective in treating certain chronic diseases, accelerating wound healing, improving hair growth, and initiating angiogenesis.
While other alternatives can function just like this peptide, each of them is associated with different harmful side effects.
This article discusses TB-500, its application for health use, and potential side effects.
What is TB-500?
TB-500 is a synthetic peptide formed from the combination of 43 different amino acids. It is the synthetic form of thymosin beta-4, a peptide that naturally occurs in the body.
TB-500 imitates the action of naturally occurring TB-4 by interacting mainly with actin, a structural protein found in almost all body cells.
Actin is one of the most important structural proteins found in human cells. Cell contraction, division, motility and cytokinesis, cell signalling, vesicle and organelle movement, maintenance of cell junctions, and cell shape are all controlled by this protein.
TB-500 upregulates actin protein to produce certain desired effects. These include enhanced healing of wounds, anti-inflammation, increased hair growth, treatment of some chronic diseases, and angiogenesis.
Differences Between TB-500 and TB-4
The only difference between TB-500 and TB-4 is their source of production. While TB-4 is naturally produced and secreted by the thymus gland, TB-500 is synthetically produced by replicating the template of TB-4.
Both molecules share several similarities and fewer differences since they have the same number of amino acids.
They also have a similar molecular and structural arrangement. Other similarities include their modes of action and effects.
Benefits Of TB-500
Peptide TB-500 has several health benefits, including its effect on the blood cells, the development of blood vessels through angiogenesis, cell migration, wound healing, and tissue repair.
All of these effects are more positively pronounced in bodybuilders and people who have hemophilia.
Enhanced Wound Healing And Reduced Scar Formation
One of the major functions of TB-500 is accelerated wound healing. When an injury is caused either due to accidental or surgical reasons, thymosin beta-500 imitates the action of TB-4 to repair and regenerate injured cells.
It does this by reducing apoptosis and preventing further inflammation and growth of microbes at the injury site.
Although TB-500 is synthetically produced and introduced into the body via external means, it is still able to stimulate the migration of platelets to the region where they are needed.
Platelet plays a lot of functions in clotting and coagulation which are both important for healing.
By initiating angiogenesis, new blood vessels and tissues are formed. TB-500 accomplishes this by causing progenitor cells to differentiate and mobilize. During the process of healing, it reduces the number of mesenchymal cells called myofibroblasts.
Myofibroblasts are generally important for tissue remodeling following an injury. However, they can lead to scar formation, and this is prevented by the action of TB-500.
Inflammation is a protective mechanism initiated by the body as a response to infections or injuries regardless of the source.
Most accidental wounds are at a very high risk of being infected due to tissue exposure or contact with the external environment. The body prevents this by activating the immune system for a swift response.
However, prolonged inflammation can lead to some health problems, such as heart disease, rheumatism, cancer, and diabetes. This is a result of the immune system destroying healthy, uninfected tissues in the body.
In the presence of glucocorticoids, TB-500 mimics its parent peptide by forming thymosin beta 500-sulfoxide, which is similar to TB-4 sulfoxide.
Inhibitory inflammatory signals produced by this sulfoxide will significantly reduce the risk of immuno-cancers and other health conditions linked to chronic inflammation.
Increased hair growth
TB-500 was first reported to promote hair growth when studied in rats. Hair-follicle stem cells are present in the dermal layer of the human skin. These cells involved in hair growth are usually long-lived and inactive unless a new division cycle is initiated.
When hair-follicle stem cells are activated, they undergo several processes, including mitosis, migration, and differentiation, to form new hair. The whole cycle is controlled by actin, which is stimulated by TB-500 to enhance hair growth.
TB-500 also aids the growth of healthy hair. It does this by stimulating the production of more keratinocytes, which in turn produce keratin. Keratin is very important for straightening and making the hair stronger.
The use of TB-500 for hair growth might be particularly useful for treating hair loss in cancer patients after recovery.
Side Effects of TB-500
There are no reported severe side effects associated with taking TB-500. However, you might experience lightheadedness, nauseous feelings, lethargy, and possibly headaches, which should subside shortly.
Since TB-500 is administered intramuscularly, there could be reddening and pain around the injection site. These are all reported only for first-time users of the injectable TB-500.
If one or two of these symptoms persist, contact your doctor immediately.
Like many other peptides, TB-500 is very effective for positively regulating and accelerating several processes in the body.
Scientists are conducting more research to figure out other health benefits of both TB-500 and TB-4. A conclusive result from these studies will lead to a breakthrough in the synthesis of a more effective peptide with almost zero side effects.